Hey everyone,
I was on youtube just now watching Gerdicks swims and one of the related links was this video by a masters swimmer who was told to have heart damage because of Vioxx use...maybe he's among us? But I thought it was a kinda funny video--I took vioxx for 4years because of my shoulders during high school before it was removed so...I am sure there are the bunch of us out there who have used it as well..
youtube.com/watch
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Vioxx (which I took for a year with no ill effects) is a COX-2 inhibitor. By inhibiting COX-2 but not COX-1, as aspirin does, the action of thromboxane is left unopposed, increasing the risk of strokes and heart attacks. I believe it is a class effect--the other COX-2 inhibitors should behave the same way. The thinking was that selective inhibition of COX-2 would provide pain relief while protecting the stomach--an improvement over drugs like aspirin or ibuprofen. In retrospect it seems obvious that there might be problems with this approach.
Vioxx (which I took for a year with no ill effects) is a COX-2 inhibitor. By inhibiting COX-2 but not COX-1, as aspirin does, the action of thromboxane is left unopposed, increasing the risk of strokes and heart attacks. I believe it is a class effect--the other COX-2 inhibitors should behave the same way. The thinking was that selective inhibition of COX-2 would provide pain relief while protecting the stomach--an improvement over drugs like aspirin or ibuprofen. In retrospect it seems obvious that there might be problems with this approach.
