I watched it some last season, but only caught the finale of this season that aired last night. Unbelievable! At least a couple people on the show lost over 50% of their original weight.
The winner, Erik, went from over 400 pounds to under 195. Look at these before and after photos:
www.nbc.com/.../erik_before1.jpgwww.nbc.com/.../erik_finale10.jpg
Hard to even believe this is the same guy!
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BTW Vioxx had indications of significant increase in blood pressure from the initial clincal trials. Outcome was predictable.
The problem with Vioxx (and other drugs in that class) is the relatively selective inhibition of Cox-2, which was thought to be beneficial in that there would be sparing of the gastric mucosa (fewer ulcers). However, by failing to inhibit Cox-1, synthesis of thromboxane (which plays a role in platelet aggregation and clot formation) could continue. Aspirin (and other nonsteroidal antiinflammatory agents) are nonselective, inhibiting both Cox-1 and Cox-2. Again, what intuitively seemed like a good idea really wasn't in the end.
BTW Vioxx had indications of significant increase in blood pressure from the initial clincal trials. Outcome was predictable.
The problem with Vioxx (and other drugs in that class) is the relatively selective inhibition of Cox-2, which was thought to be beneficial in that there would be sparing of the gastric mucosa (fewer ulcers). However, by failing to inhibit Cox-1, synthesis of thromboxane (which plays a role in platelet aggregation and clot formation) could continue. Aspirin (and other nonsteroidal antiinflammatory agents) are nonselective, inhibiting both Cox-1 and Cox-2. Again, what intuitively seemed like a good idea really wasn't in the end.
