At our SCM meet this past weekend we had an out-of-state visitor swimming. She was a very serious swimmer, arrived a week early to acclimate, came with a bit of an entourage, and did some pretty amazing times (45-49). We also saw her taking frequent hits from a very large inhaler always just before her races as she was warming up and behind the blocks. Any thoughts?.
Parents
Former Member
I found this excerpt although I cannot verify the source or the exact procedures of the experiment, but I will look for it.
There was other evidence that the HFA formulation delivers a lower/less effective dose on a per acutation basis than the CFC product. In the single dose, dose ranging study in adults, and in the single dose methacholine challenge study in adults one and two acutations of albuterol CFC were statistically indistinguishable in terms of effect, whereas significant differences were seen between one and two acutations of albuterol HFA. Finally, the combined adolescent/adult studies showed that the HFA formulation had a longer median time to onset of effect(4.2-9.6 minutes versus 3.6-4.2 minutes), had a shorter duration of effect(1.55-3.30 hours versus 2.29 - 3.69 hours), and was associated with more albuterol 'back up' use than the CFC formulation.
Methacholine is a drug that will induce bronchioconstriction in individuals with bronchiohyperactivity (asthma, COPD) when inhaled. So a methacholine challenge is when a subject inhales methacholine.
I found this excerpt although I cannot verify the source or the exact procedures of the experiment, but I will look for it.
There was other evidence that the HFA formulation delivers a lower/less effective dose on a per acutation basis than the CFC product. In the single dose, dose ranging study in adults, and in the single dose methacholine challenge study in adults one and two acutations of albuterol CFC were statistically indistinguishable in terms of effect, whereas significant differences were seen between one and two acutations of albuterol HFA. Finally, the combined adolescent/adult studies showed that the HFA formulation had a longer median time to onset of effect(4.2-9.6 minutes versus 3.6-4.2 minutes), had a shorter duration of effect(1.55-3.30 hours versus 2.29 - 3.69 hours), and was associated with more albuterol 'back up' use than the CFC formulation.
Methacholine is a drug that will induce bronchioconstriction in individuals with bronchiohyperactivity (asthma, COPD) when inhaled. So a methacholine challenge is when a subject inhales methacholine.
